Jeremy S. Edwards

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Dr. Edwards’ research interests are centered on two areas: spatial-temporal modeling of signaling networks and functional genomics tool development. The development of spatially realistic simulations helps in understanding the importance of spatial regulation in signal transduction. Ongoing research will provide an unprecedented level of detail regarding the changing topography of membrane organization and contribute new insight into the nature and assembly of membrane micro-domains controlling signal transduction and membrane trafficking in eukaryotic cells.

Professional Experience

• Present:  Professor, Department of Chemical & Nuclear Engineering • University of New Mexico, Albuquerque, NM.
• 2005 - : Assistant Professor, Department of Molecular Genetics and Microbiology• University of New Mexico, Albuquerque, NM.
• 1999 - 2005: Assistant Professor, Department of Chemical Engineering • University of Delaware, Newark, DE.
• 1999 - 2000: Postdoctoral Fellow, Harvard Medical School, Boston, MA.

Ongoing Research Support:

• National Institutes of Health - 09/30/00-09/30/05
  COBRE: Structural and Functional Genomics
• US Department of Energy - 09/1/01-08/31/05
  The Molecular Basis for Metabolic and Energetic diversity
  The major goals of this projects are to study the metabolic regulation in DOE relevant microorganisms.

Pending Research Support:

• 0506423 - 07/1/05-06/31/08
  NSF/NCI NSF/NCI Intergency Program in Mult-Scale Modeling Mapping and Modeling ErbB receptor Membrane Topography
  This project will support an interdisciplinary team1) to collect quantitative experimental data on the spatial heterogeneity of ErbB receptor expression in endometial cancer cell lines and within endometrial cancer tissues and 2) to develop mltiscale models that can analyze and integrate these data.

Selected Publications:

• Chatterjee A., Mayawala K., Edwards J. S. & Vlachos D. G., Time accelerated Monte Carlo simulations of biological networks using the binomial {tau}-leap method. Bioinformatics (2005).
• Gadkar K. G., Doyle III F. J., Edwards, J. S. & Mahadevan, R., Estimating optimal profiles of genetic alterations using constraint-based models. Biotechnol Bioeng 89, 243-51 (2005).
• Mayawala K., Vlachos D. G. & Edwards J. S., Heterogeneities in EGF receptor density at the cell surface can lead to concave up scatchard plot of EGF binding. FEBS Lett 579, 3043-7 (2005) .
• Merritt J., Butz J. A., Ogunnaike,B. A. & Edwards J. S., J. S. Parallel analysis of human glucose-6-phosphate dehydrogenase single-nucleotide mutants via functional complementation in S. cerevisiae using polymerase colonies. Biotech Bioeng In press (2005) .
• Butz J., Goodwin K. & Edwards J. S., Detecting changes in the relative expression of K-ras2 splice variants using polymerase colonies. Biotechnol Prog 20, 1836-1839 (2004) .
• Butz J., Yan H., Mikkilineni V. & Edwards J. S., Detection of allelic variations of human gene expression by polymerase colonies. BMC Genetics 5 (2004).
• Goodkind J. R. & Edwards J. S., Gene Expression Measurement Technologies: Innovations and Ethical Considerations. Computers & Chemical Engineering In Press (2004).
• Mayawala K., Gelmi C. A. & Edwards J. S., MAPK cascade possesses decoupled controllability of signal amplification and duration. Biophys J 87, L01-2 (2004).
• Merritt J. & Edwards, J. S., Assaying gene function by growth competition experiment. Metab Eng 6, 212-219 (2004).
• Mikkilineni V., Mitra R. D., DiTonno J. R., Merritt J., Church G. M., Ogunnaike B. A. & Edwards J. S., Digital Quantitative Measurements of Gene Expression. Biotech Bioeng 86, 117-124 (2004) .
• Mutalik V. K., Singh A. P., Edwards J. S. & Venkatesh K. V., Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross-talk. FEBS Letters 558, 79-84 (2004). 
  
  For complete list click here.